ODCs

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1 OMIM reference -
1 associated gene
9 signs/symptoms

PROTEIN INTERACTIONS: 1

Idiopathic juvenile osteoporosis

2 OMIM references -
4 associated genes
6 signs/symptoms

Coats disease

Idiopathic juvenile osteoporosis

NDP	(UniProt - OMIM)		DKK1	(UniProt - OMIM)
			LRP5	(UniProt - OMIM)
			WNT1	(UniProt - OMIM)
			WNT3A	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	NDP	(0.63)	LRP5

Citations in the biomedical literature:

Coats disease		Idiopathic juvenile osteoporosis
	Synonym(s): - Congenital retinal telangiectasia - Leber miliary aneurysm		Synonym(s): - IJO - Juvenile osteoporosis

	Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease

	Classification (ICD10): - Diseases of the eye and adnexa -		Classification (ICD10): - Diseases of the musculoskeletal system and connective tissue -

	Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: normal Type of inheritance: sporadic		Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: - Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - 1 MeSH reference: D058456		External references: 2 OMIM references - No MeSH references

Coats disease		Idiopathic juvenile osteoporosis
	Very frequent - Retinal vascular anomalies / retinal telangiectasia - Strabismus / squint Frequent - Glaucoma - Macular dystrophy / absence / hypoplasia of the macula - Retinal detachment Occasional - Aniridia / iris hypoplasia - Anterior chamber anomaly - Cataract / lens opacification - Visual loss / blindness / amblyopia		Very frequent - Bone pain - Mutiple fractures / bone fragility - Osteoporosis / osteopenia / demineralisation / osteomalacia / rickets Frequent - Abnormal gait - Motor deficit / trouble Occasional - Kyphosis